DEPRESSION OF RESISTANCE AGAINST SALMONELLA INFECTION IN SARCOMA 180-BEARING MICE AND ITS RESTORATION BY SALMONELLA MINI-CELLS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 54  (3) , 91-96
Abstract
Decreased resistance against Salmonella infection was a result of reduction of macrophage activities in [mouse] Sarcoma 180 [S180]-bearing mice. Mean survival day of S180-bearing mice was markedly reduced to 1.4 .+-. 0.5 days after challenge with 1 .times. 108 of S. typhimurium LT2 cells in contrast with 6.8 .+-. 1.9 days for normal mice. Of S180-bearing mice, 80% died within 14 days after challenge with 1 .times. 106 of LT2 cells; all normal mice survived > 30 days after challenge with .ltoreq. 3 .times. 106 LT2 cells. Chemotactic and O2- producing activities of macrophages collected from S180-bearing mice were restored to normal levels after treatment with Salmonella mini-cells. Bactericidal activity of macrophages was also restored by mini-cell treatment. The restoration of the resistance to Salmonella was accompanied with increases of macrophage activities.