Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding
- 3 October 1980
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 210 (4465) , 88-90
- https://doi.org/10.1126/science.6251550
Abstract
Antidepressants compete at several neurotransmitter receptor binding site, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and beta-adrenergic receptors. The decrease in the number of receptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.This publication has 19 references indexed in Scilit:
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