Influence of Food on the Pharmacokinetics of Quinapril and Its Active Diacid Metabolite, CI-928

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Abstract
A randomized two‐way crossover study was conducted in 12 healthy volunteers to assess the effect of food on the pharmacokinetics of quinapril (CI‐906) and its active metabolite, CI‐928, after quinapril dosing. Forty‐milligram oral quinapril doses were administered in a fasted or a fed state with a one‐week washout period between treatments. No significant treatment differences were observed in quinapril and CI‐928 values for maximum plasma concentration, area under the plasma concentration‐time curve, or percentage of dose excreted in the urine. Small but significant increases of less than 0.5 hour in quinapril and CI‐928 tmax values were observed after consumption of food. The pharmacokinetic profiles of quinapril and CI‐928 were not significantly altered by the administration of food.

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