Fly models of Huntington's disease
Open Access
- 12 August 2003
- journal article
- review article
- Published by Oxford University Press (OUP) in Human Molecular Genetics
- Vol. 12 (suppl 2) , R187-R193
- https://doi.org/10.1093/hmg/ddg271
Abstract
Can Drosophila models be engineered that accurately reflect Huntington's disease (HD) and other neurological diseases and can they contribute to the search for treatments and cures? A number of publications seem to provide a resounding yes to that question. Here we seek to review some of the salient features of these models.Keywords
This publication has 73 references indexed in Scilit:
- Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of PathogenesisScience, 2003
- Teaching old drugs new tricksTrends in Neurosciences, 2002
- Representation of the Glomerular Olfactory Map in the Drosophila BrainCell, 2002
- Spatial Representation of the Glomerular Map in the Drosophila ProtocerebrumCell, 2002
- Investigating protein conformation–based inheritance and disease in yeastPhilosophical Transactions Of The Royal Society B-Biological Sciences, 2001
- A Drosophila model of Parkinson's diseaseNature, 2000
- Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in BrainScience, 1997
- Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic MiceCell, 1996
- Neuronal differentiation in the Drosophila ommatidiumDevelopmental Biology, 1987
- On the relationship between senescence and age-related changes in two wild-type strains of Drosophila melanogasterExperimental Gerontology, 1978