Repair of sublethal and potentially lethal damage in lung cells using anin vitrocolony method

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Abstract
The repair of radiation damage was measured in mouse lung using an in vitro colony assay. Following a single dose of 10.5 Gy [gray] delivered to the lung in vivo, 6 h after irradiation, an increase of the fraction of surviving cells was observed, which did not change further between 6 and 24 h (repair of potentially lethal damage). A similar observation was made using a split-dose method (repair of sublethal damage). The extent of radiation repair is comparable with that of other rodent cells [mouse and rat cell lines] irradiated in vivo. The significance of these results is discussed in relation to the late effects observed following irradiation of lung tissue.