A glucagon-like peptide, structurally related to mammalian oxyntomodulin, from the pancreas of a holocephalan fish, Hydrolagus colliei
- 1 August 1987
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 245 (3) , 851-855
- https://doi.org/10.1042/bj2450851
Abstract
The pancreatic islets of the holocephalan fishes contain, in addition to A-, B- and D-cells, X-cells, which are immunoreactive towards antisera directed against the N-terminal region of glucagon but not towards antisera directed against the C-terminal region. A 36-amino-acid-residue peptide was isolated from the pancreas of a holocephalan fish, the Pacific ratfish (Hydrolagus colliei), that shows homology (69%) to mammalian glucagon in its N-terminal region and is reactive towards an N-terminally directed antiserum. Reactivity towards C-terminally directed antisera is prevented by the presence of a 7-residue C-terminal extension to the glucagon sequence that shows limited homology to the C-terminal region of glucagon-37 (oxyntomodulin). It is proposed that this peptide represents a major storage product of the islet X-cell.This publication has 13 references indexed in Scilit:
- The primary structure of ratfish insulin reveals an unusual mode of proinsulin processingFEBS Letters, 1986
- Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequenceFEBS Letters, 1986
- Primary structure of glucagon from an elasmobranchian fish, Torpedo marmorataGeneral and Comparative Endocrinology, 1985
- Primary structure of glucagon and a partial sequence of oxyntomodulin (glucagon-37) from the guinea pigRegulatory Peptides, 1985
- Fragments of prosomatostatin isolated from a human pancreatic tumourMolecular and Cellular Endocrinology, 1984
- The isolation and sequencing of human gastric inhibitory peptide (GIP)FEBS Letters, 1984
- Isolation of glucagon‐37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno‐ileumFEBS Letters, 1982
- The primary structure of porcine glicentin (proglucagon)Regulatory Peptides, 1981
- Primitive Islets Contain Two Populations of Cells with Differing Glucagon ImmunoreactivityDiabetes, 1981
- Isolation of a Glucagon-containing Peptide: Primary Structure of a Possible Fragment of ProglucagonProceedings of the National Academy of Sciences, 1973