Diagnosis of Systemic Lupus Erythematosus by Electrophoresis

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Abstract
Antigen characteristic of systemic lupus erythematosus has been demonstrated in the sera of 35 out of 44 patients with active lupus disease by a method of paper electrophoresis. The level of the antigen reflects the acuteness of the pathological process, and a study of changes in the antigen level provides objective data on the progress of the disease, the efficiency of therapy, and the prognosis for individual patients. Steroid hormone therapy depresses the level of lupus antigen, probably by suppressing the activity of the disease process. In the course of severe L. E. nephritis, especially with renal failure, and in the presence of sclerotic and destructive changes in the internal organs, the lupus antigen could not be isolatad.