Glucagon: Physiologic and Clinical Considerations

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Abstract
ALTHOUGH glucagon (hyperglycemic glycogenolytic factor) was discovered and named thirty-four years ago, it has yet to achieve unqualified acceptance as a hormone.1 , 2 With one possible exception, no clinical disorder attributable to a deficiency of glucagon has been identified.3 Nor is there general agreement concerning the site of origin of this substance.4 , 5 These objections, however, are not as decisive as might at first be imagined. For example, there is no question about the hormonal nature of epinephrine; yet no syndrome referable to a deficiency of adrenal medullary secretion has been described. And, although the site of origin of glucagon has not . . .