Alterations of local cerebral blood flow during hypoxic hypoxia; 14C-iodoantipyrine autoradiographic study.
- 1 January 1984
- journal article
- research article
- Published by Japan Society of Histochemistry & Cytochemistry in ACTA HISTOCHEMICA ET CYTOCHEMICA
- Vol. 17 (5) , 499-506
- https://doi.org/10.1267/ahc.17.499
Abstract
The effects of hypoxic hypoxia on local cerebral blood flow was studied by using 14C-iodoantipyrine autoradiography. Hypoxia (8% O2 and 6% O2 for 30 min) was induced in mice without control of the temperature and blood pressure. Percent decreases in cerebral O tension (P cortex O2) during 8% O2 and 6% O2 hypoxia were 80% and 92%, respectively. Under normal conditions (21%O2), P cortex O2 wa s17.4 .+-. 4.0 mmHg. Optical density (OD), main factors responsible for the measurement of local cerebral blood flow were observed by the scanning micro-densitometer. The pyramidal cell layer of the hippocampus, choroid plexus and venous (sinus) blood did not decrease in ODs during hypoxic hypoxia, while OD in all other cerebral regions examined significantly decreased as compared with that of the control (P < 0.01). In others, amygdala showed a marked decrease (.apprx. 30%) in OD during hypoxic hypoxia.This publication has 1 reference indexed in Scilit:
- Glucose uptake in mouse brain regions under hypoxic hypoxiaNeurochemical Research, 1981