Heat‐induced cytotoxicity in H2O2‐resistant Chinese hamster fibroblasts

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Abstract
Hydrogen‐peroxide‐resistant Chinese hamster fibroblasts, derived from the HA‐1 cell line, were isolated following continuous culturing in the presence of progressively increasing concentrations of hydrogen peroxide. The hydrogen‐peroxide‐resistant phenotype has been stable for over 360 days following removal from H2 O2 stress. These H2 O2‐resisant cell lines demonstrate increased resistance to hyperthermic cell killing, mediated by continuous heating at 43°C but not 45°C. The relationship between mammalian cellular adaptation to oxidative stress mediated by H2 O2 and resistance to 43°C hyperthermia is discussed.