Effects of Thyroid Hormone on Lipide Metabolism in the Rat11

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Abstract
On a sterol-free diet, which contained only 10% fat, hypothyroid rats exhibited hypercholesterolemia but maintained normal levels of liver cholesterol. On the same diet, hyperthyroid rats maintained subnormal concentrations of nonesterified cholesterol in plasma and greater than normal concentrations in liver. Differences in the concentrations of lipide phosphorus in serum among hyperthyroid and hypothyroid rats and their respective controls were not significant; however, the hepatic levels of lipide phosphorus and total fatty acids in the hyperthyroid rats were higher than those in their normal litter mates. After sodium l-C14-acetate was administered intraperitoneally, more carbon-14 was recovered in the digitonfn-precipitable sterols, fatty acids and phospholipides from livers of hyperthyroid rats than in these substances from the livers of their normal controls. There was no significant difference between hypothyroid rats and their normal litter mates with regard to the levels of the carbon- 14 in these lipides.