CORRELATIONS OF INTERNAL AND EXTERNAL PANCREATIC SECRETION

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Abstract
In previous communications, one of us (G. de T.1) reported studies of the histology of the tail of the pancreas after it had been excluded from the rest of the gland and its external secretion had stopped. The splenic portion of the pancreas was isolated in twenty-five dogs, and specimens were taken from two days to one year at intervals. After a short period of edema, a gradual increase in connective tissue occurred, first around and then within the lobules, resulting in a pancreatic cirrhosis. The ducts were first dilated, then showed proliferation and infolding of their epithelium. A number of minute ducts appeared. The islands showed edema for the first two weeks; later large solid cell complexes appeared showing the vascular arrangement and staining properties of islet tissue. Such an isolated tail did not tend to degenerate and undergo absorption for at least three months if a free

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