Synthesis, Chemical Properties, and Preliminary Evaluation of Substituted CBI Analogs of CC-1065 and the Duocarmycins Incorporating the 7-Cyano-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one Alkylation Subunit: Hammett Quantitation of the Magnitude of Electronic Effects on Functional Reactivity
- 1 January 1996
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 61 (15) , 4894-4912
- https://doi.org/10.1021/jo9605298
Abstract
No abstract availableKeywords
This publication has 56 references indexed in Scilit:
- Duocarmycins, Potent Antitumor Antibiotics Produced by Streptomyces sp. Structures and Chemistry.CHEMICAL & PHARMACEUTICAL BULLETIN, 1995
- A potent, simple derivative of an analog of the CC-1065 alkylation subunitBioorganic & Medicinal Chemistry Letters, 1991
- Synthesis and preliminary evaluation of (+)-CBI-indole2: an enhanced functional analog of (+)-CC-1065Bioorganic & Medicinal Chemistry Letters, 1991
- Synthesis of new cyclopenta-fused polycyclic aromatic hydrocarbon isomers of cata-annelated benzenoid systemsThe Journal of Organic Chemistry, 1987
- A convenient, mild method for the cyclization of 3- and 4-arylalkanoic acids via their trifluoromethanesulfonic anhydride derivativesThe Journal of Organic Chemistry, 1984
- Total synthesis of (.+-.)-5,6-oxido-7,9-trans,11,14-cis-eicosapentaenoic acid, a possible precursor of SRSAJournal of the American Chemical Society, 1979
- γγ‐Disubstituted Itaconic Acids. Part 1. The Stobbe condensation of 1‐arylnaphthyl ketones with diethyl succinateHelvetica Chimica Acta, 1979
- The Stobbe Condensation with Sodium Hydride1Journal of the American Chemical Society, 1950
- Synthesen in der Naphtalingruppe. I. Über die Synthese von 1‐Aryl‐4‐oxy‐naphtalin‐2‐carbonsäuren, 1‐Aryl‐4‐oxy‐naphtalinen und 3,4‐Benzo‐2‐oxy‐fluorenonenEuropean Journal of Organic Chemistry, 1936
- Eine neue Synthese der TeraconsäureEuropean Journal of Inorganic Chemistry, 1893