Optimizing selection of restriction enzyme in the search for ONA variants
- 1 January 1984
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 12 (23) , 9209-9226
- https://doi.org/10.1093/nar/12.23.9209
Abstract
A model is developed for predicting the relative efficiencies of different enzymes for detecting DNA variants when such variants are the result of single base-pair changes. 71 enzymes are analyzed for this ability in human DNA. Their relative ranked efficiencies are influenced by the sizes of the probes used, and the size of the smallest detectable fragment produced.Keywords
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