Parvovirus Infection

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Abstract
The article by Plummer and colleagues in this issue of the Journal draws attention to the role of parvovirus infection in human disease.1 Although parvovirus infections of animals have been recognized for some time, only within the past decade has an association with human disease been clearly demonstrated. The first link in the chain of evidence was a chance discovery. In the mid-1970s, while new tests to detect hepatitis B surface antigen were being evaluated, several units of blood demonstrated "reactivity" by counterimmunoelectrophoresis but were subsequently negative for this antigen by more sensitive assays.2 A detailed electron microscopical evaluation was . . .