EFFECTS OF REPEATED ORAL DOSES OF QUININE AND QUINIDINE ON THE BLOOD PRESSURE AND RENAL CIRCULATION OF DOGS WITH EXPERIMENTAL NEUROGENIC HYPERTENSION

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Abstract
Oral doses of quinine or quinidine of the order of 10-15 mg./kg. administered to dogs 3 times a day for several days had the following effects: (a) in normal dogs, a sustained renal hyperemia (as measured by clearance methods) without much change in blood pressure; (b) in dogs with neurogenic hypertension, a sustained fall in the blood pressure without any decrease in renal circulation. With quinine there is actually an increase in renal blood flow. Quinidine had a greater depressor effect on the blood pressure than quinine. These effects were achieved with plasma concn. of cinchona alkaloid in the range of 1-4 mg./l.

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