Subanaesthetic halsothane: Its effect on regulation of ventilation and relevance to the recovery room
- 1 November 1978
- journal article
- research article
- Published by Springer Nature in Canadian Journal of Anesthesia/Journal canadien d'anesthésie
- Vol. 25 (6) , 488-494
- https://doi.org/10.1007/bf03007411
Abstract
Ventilation and the ventilatory response to a steady-state of isocapnic hypoxaemia were measured in six healthy volunteers, both awake and while sedated with low doses of halothane (0.05 and 0.1 MAC). Halothane sedation markedly reduced ventilatory responses to sustained hypoxaemia, in a dose-related fashion. We estimated the length of time after anaesthesia that halothane 0.1 MAC would be present in patients in the recovery room. In five healthy patients who had halothane anaesthesia with a mean duration of one hour, halothane 0.1 MAC or more persisted for approximately one hour. We conclude that, during emergence from halothane anaesthesia, patients may have a significant impairment of the ventilatory response to hypoxaemia, which persists for some time even after regaining consciousness. Chez six volontaires en bonne santé tantôt éveillés, tantôt sous sedation légère à faible dose ďHalothane (0,05 et 0,1 MAC), on a mesuré la ventilation et la réponse ventilatoire à ľhypoxémie isocapnique soutenue. Proportionnellement à la dose administrée, ľHalothane a fortement réduit la réponse ventilatoire à ľhypoxémie soutenue. Dans un deuxième temps, nous avons cherché à estimer combien de temps, au sortir ďune aneslhésieà ľHalothane, on peut encore déceler en salle de réveil des concentrations ďHalothane de ľordre de 0,1 MAC. Chez cinq malades en bonne santé pour une heure ďanesthésie à ľHalothane, des concentrations de 0,1 MAC ou plus ont persisté en salle de réveil pendant à peu près une heure. Nous en concluons qu’au sortir ďune anesthésie à ľHalothane, la réponse ventilatoire à ľhypoxémie peut être nettement réduite et que ce phénomène persiste même après le retour à la conscience.Keywords
This publication has 11 references indexed in Scilit:
- Hypoxic ventilatory responses during thiopentone sedation and anaesthesia in manCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 1978
- Regulation of RespirationNew England Journal of Medicine, 1977
- Depression of Hypoxic Ventilatory Response by Nitrous OxideAnesthesiology, 1976
- Assessment of ventilatory response to hypoxia: methods and interpretation.1976
- Hypoxemia during and after AnesthesiaAnesthesiology, 1972
- Is the End-tidal Anesthetic Partial Pressure an Accurate Measure of the Arterial Anesthetic Partial Pressure?Anesthesiology, 1971
- Minimum Alveolar Concentrations in Man on Awakening from Methoxyflurane, Halothane, Ether and Fluroxene AnesthesiaAnesthesiology, 1970
- Hypoxic ventilatory drive in normal manJournal of Clinical Investigation, 1970
- The Effects of Ventilation and Anesthetic Solubility on Recovery from AnesthesiaAnesthesiology, 1969
- Minimum Alveolar Anesthetic ConcentrationAnesthesiology, 1965