Studies on drug induced lupus erythematosus in mice. I. Drug induced antinuclear antibodies (ANA).
- 1 June 1972
- journal article
- Vol. 11 (2) , 265-76
Abstract
Hydralazin, isoniazid, procainamide, α-methyldopa and chlorthalidone were given orally to mice of three inbred strains: BALB/CJ, C57/BL/6J and A/JAX. All drugs significantly increased the frequency of antinuclear antibodies (ANA). The results were most marked after 8 months of treatment. Although a slight preponderance of females was observed for ANA frequencies in BALB/CJ and A/JAX mice, this was significant only for hydralazin- and procainamide-treated animals. C57/BL/6J males appeared to respond better than females. Genetical factors appear of importance in the induciton of drug induced lupus erythematosus (DILE).This publication has 23 references indexed in Scilit:
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