Protection against keratoconjunctivitis shigellosa induced by immunization with outer membrane proteins of Shigella spp

Abstract
Active immunization of guinea pigs and rabbits with outer membrane proteins (OMP) isolated from S. flexneri 3a and S. sonnei phase I protected the animals against keratoconjunctivitis shigellosa induced with the homologous or heterologous strain. Protection was achieved in rabbits after passive immunization with anti-OMP immune serum. Active immunization with lipopolysaccharide of S. flexneri 3a did not protect rabbits against keratoconjunctivitis shigellosa.