BIOCHEMICAL AND MORPHOLOGICAL INVESTIGATIONS OF THE TOXICITY OF A CAPMUL PREPARATION AND A BILE-SALT EDTA SOLUTION IN PATIENTS WITH BILE-DUCT STONES

  • 1 January 1984
    • journal article
    • research article
    • Vol. 79  (4) , 291-298
Abstract
Patients (17) with bile duct calculi were treated alternately with a preparation of glycerol octanoate and a bile salt-EDTA solution via a nasobiliary tube. Of 14 patients (group 1), it was necessary to operate on 4 immediately after irrigation therapy; success resulted from this conservative therapy in 8 (57%) cases and 2 were unchanged. Laboratory investigations showed a decrease in Zn and Cu concentrations in the serum. Of the patients, 50-60% suffered from vomiting and diarrhea. For 3 patients (group 2), there was an interval of 6-26 days between the end of the therapy and operation. Histological findings in the patients in group 1 and 2 subjected to operation included acute ulcerative and chronic inflammation in gallbladder and common bile duct walls. Since the alterations were of minor degree in 4 of the 7 patients who subsequently underwent surgery the risk of irradiation therapy seemed to be acceptable.