INHIBITION OF IMMEDIATE HYPERSENSITIVITY REACTION BY A NEW DRUG, RU-3II56

  • 1 January 1984
    • journal article
    • research article
    • Vol. 15  (3) , 353-373
Abstract
The effects of Ru-31156 on type I allergic reactions were studied. Seven-day homologous PCA [passine cutaneous anaphylaxis] in guinea pigs was significantly inhibited by oral doses of this drug. The maximum inhibition was observed when the drug was given 30 minutes prior to challenge. Forty-eight-hour homologous PCA was significantly inhibited in rats, and this inhibition was maximal when the drug was given 10 min prior to challenge. Orally-administered RU-31156 gave significant inhibition of induction of experimental asthma symptoms in guinea pigs when it was given 1 or 2 h prior to challenge. The drug significantly inhibited the asthmatic reaction of experimental asthma in rats when it was given 10 min prior to challenge. RU-31156 significantly inhibited histamine and SRS-A [slow reacting substance of anaphylaxis] release from the lung tissue of passively sensitized guinea pigs. The combined use of isoproterenol or theophylline with RU-31156 did not enhance the inhibitory activity of the drug. RU-31156 did not produce any effect on the histamine release induced by calcium ionophore A 23187 [calcimycin]. Ru-31156 inhibited the Schultz-Dale reaction in the tracheal muscle and the ileum of guinea pigs, but it did not show any antihistaminic action in these organs.