Decreased natural killer activity in patients with liver cirrhosis

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Abstract
Natural killer (NK) activity of peripheral blood mono‐nuclear cells from patients with non‐alcoholic liver cirrhosis (LC) (30 cases), patients with other, non‐malignant diseases (41 cases), and healthy subjects (36 cases) were investigated using 51Cr‐labelled CCRF‐CEM and K562 target cells. NK activity in patients with LC was lower than that in healthy subjects and that in patients with other, non‐malignant diseases. The differences were statistically significant by Student's t‐test and the Wilcoxon rank test. There was no difference of NK activity between serologically hepatitis B surface antigen (HBsAg)‐positive and ‐negative patients.