Identification of the mammalian homologues of the Drosophila timeless gene, Timeless11
Open Access
- 28 December 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 441 (3) , 427-431
- https://doi.org/10.1016/s0014-5793(98)01597-x
Abstract
We have identified novel mammalian homologues of a Drosophila clock gene, timeless, and designated them as human TIMELESS1 (hTIM1) and mouse Timeless1 (mTim1), respectively. These genes were mapped by FISH to chromosomal regions 12q12‐13 in human and 10D3 in mouse. The deduced amino acid sequences of hTim1 and mTim1 proteins were 1208 and 1197 amino acids in length and shared 83% identity. Northern blot analysis identified a single transcript of 4.5 kb expressed widely in many tissues examined. Unlike the Drosophila counterpart, the levels of the mTim1 transcript exhibited no prominent circadian oscillation in the mouse brain.Keywords
This publication has 29 references indexed in Scilit:
- Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the ratPublished by Elsevier ,2003
- Role of the CLOCK Protein in the Mammalian Circadian MechanismScience, 1998
- The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factorsProceedings of the National Academy of Sciences, 1998
- Independent Photoreceptive Circadian Clocks Throughout DrosophilaScience, 1997
- cDNA Cloning and Tissue-Specific Expression of a Novel Basic Helix–Loop–Helix/PAS Protein (BMAL1) and Identification of Alternatively Spliced Variants with Alternative Translation Initiation Site UsageBiochemical and Biophysical Research Communications, 1997
- Regulation of Nuclear Entry of the Drosophila Clock Proteins Period and TimelessNeuron, 1996
- Regulation of the Drosophila Protein Timeless Suggests a Mechanism for Resetting the Circadian Clock by LightCell, 1996
- A light-entrainment mechanism for the Drosophila circadian clockNature, 1996
- Loss of Circadian Behavioral Rhythms and per RNA Oscillations in the Drosophila Mutant timelessScience, 1994
- Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levelsNature, 1990