Endocrine evaluation of forty female-to-male transsexuals: Increased frequency of polycystic ovarian disease in female transsexualism
- 1 February 1986
- journal article
- research article
- Published by Springer Nature in Archives of Sexual Behavior
- Vol. 15 (1) , 69-78
- https://doi.org/10.1007/bf01542305
Abstract
A retrospective study of 40 female-to-male transsexuals was performed to investigate the frequency of endocrine dysfunction prior to hormonal treatment with testosterone. Two patients had laparoscopic evidence of polycystic ovarian disease (PCOD) prior to androgen treatment. Nine additional subjects had clinical evidence of PCOD, including ultrasonographic evidence of multicystic and enlarged ovaries in three patients and/or evidence of hirsutism and oligomenorrhea associated with increased androgen levels and/or an increased plasma luteinizing hormone (LH)/follicle-stimulating hormone (FSH) ratio. Two subjects had evidence of gonadal dysgenesis. Plasma levels of testosterone, prolactin, LH/FSH ratio, and dehydroepiandrosterone sulfate were significantly increased in 30 female transsexuals prior to testosterone treatment when compared to normal adult female controls studied in the early follicular phase of the menstrual cycle. These data indicate that female transsexuals have an increased incidence of endocrine dysfunction (32.5%) which should be investigated prior to hormonal treatment.This publication has 28 references indexed in Scilit:
- THE FEMINISATION OF GONADOTROPHIN RESPONSES IN INTACT MALE TRANSSEXUALSClinical Endocrinology, 1984
- Normal Plasma Gonadotropin Response to Gonadotropin-Releasing Hormone after Diethylstilbestrol Priming in Transsexual WomenJournal of Clinical Endocrinology & Metabolism, 1983
- 5 Hormones and psychosexual differentiation: implications for the management of intersexuality, homosexuality and transsexualityClinics in Endocrinology and Metabolism, 1982
- Testicular function in transsexual menArchives of Sexual Behavior, 1982
- REVIEW ARTICLE: THE POLYCYSTIC OVARY SYNDROMEClinical Endocrinology, 1980
- Plasma testosterone values in transsexual womenArchives of Sexual Behavior, 1977
- FEMALE TRANS-SEXUALIST WITH ABNORMAL KARYOTYPEThe Lancet, 1976
- Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome.Journal of Clinical Investigation, 1976
- Sex chromosome abnormality in a patient with transsexualism.BMJ, 1972
- Two Cases of Transsexualism with Gonadal DysgenesiaThe British Journal of Psychiatry, 1971