EFFECT OF A PROTEIN-FREE DIET, A SUGAR DIET AND OF CARBON-TETRACHLORIDE ADMINISTRATION ON TOXICITY AND RATE OF METABOLISM OF DIMETHYLNITROSAMINE IN DIFFERENT RAT STRAINS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 58  (2) , 225-229
Abstract
A Porton and a hooded rat strain showed a raised LD50 for dimethylnitrosamine (DMN) when pre-conditioned on a protein-free and/or a sugar diet. Little or no such differential toxicity between normal and diet-fed animals was found for rats of the Wistar, BDIX and CFY strains. Pre-treatment with CCl4 did not alter significantly the toxicity of DMN in the Wistar strain. All 5 rat strains treated by diet or CCl4 administration metabolized DMN at a very much slower rate than did the controls, the rates for the different strains being quantitatively similar. The toxicity of DMN is not necessarily related to its rate of metabolism and that the effect of diet or CCl4 treatment on DMN toxicity is dependent on the rat strain used.