Properties and significance of a small marker chromosome in amniotic fluid cells
- 1 October 1980
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 18 (4) , 253-256
- https://doi.org/10.1111/j.1399-0004.1980.tb00882.x
Abstract
We report the presence of a small supernumerary metacentric chromosome in an amniotic fluid cell culture. The extra chromosome was inherited from the mosaic mother, and was characterized by the presence of four satellite regions, two on each side of the centromere. The pregnancy proceeded to term, and our findings were confirmed in the clinically normal offspring. The problems posed by the presence of the marker chromosome, in terms of both cytogenetic diagnosis and genetic counseling, are discussed in the light of similar cases from the literature.Keywords
This publication has 9 references indexed in Scilit:
- C-bands in seven cases of accessory small chromosomesClinical Genetics, 2008
- Nucleolus-organiser regions in familial extra metacentric human chromosomesHeredity, 1980
- Discovery of an inherited bisatellited metacentric microchromosome in amniotic cell culturePathology, 1980
- Discovery of an inherited bisatellited metacentric microchromosome in amniotic cell cultureClinical Genetics, 1979
- Accessory small chromosomes in amniotic fluid cellsClinical Genetics, 1979
- A Familial Extra Small Marker Autosome in Persons with Normal PhenotypeHuman Heredity, 1979
- Significance of detection of extra metacentric microchromosome in amniotic cell culture.Journal of Medical Genetics, 1978
- Small marker chromosome mosaicism confirmed in two cases ascertained prenatallyAmerican Journal of Medical Genetics, 1978