GENETIC SEX: CHROMATIN TEST VERSUS GONADAL HISTOLOGY

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Abstract
Traditionally, the sex of an individual has been judged on the basis of the morphology and histology of his gonads. The present report concerns the histology of a gonad from each of 3 patients with the Klinefelter syndrome. In all 3 gonads there were a few tubules with the male type gametogenesis advanced to spermatid formation, even though all 3 individuals had female type chromatin in the somatic cells of their oral smear. Since the significance of the chromatin mass in the somatic cells of normal females is not known, Barr has pointed out that it is pre- mature to equate female-type nuclei with genetic femaleness.

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