1,25-Dihydroxycholecalciferol: Metabolite of Vitamin D 3 Active on Bone in Anephric Rats
- 9 June 1972
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 176 (4039) , 1146-1147
- https://doi.org/10.1126/science.176.4039.1146
Abstract
Nephrectomy prevents completely the bone calcium mobilization response to 25-hydroxycholecalciferol. In contrast it does not prevent this response to 1,25-dihydroxycholecalciferol. Because it is known that the kidney is the site of 1,25-dihydroxycholecalciferol formation, these results provide evidence that 1,25-dihydroxycholecalciferol or a further metabolite thereof and not 25-hydroxycholecalciferol is the metabolically active form of vitamin D 3 responsible for bone calcium mobilization.Keywords
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