Les différents modes d’expression du test au monoxyde de carbone en régime stable: discussion et proposition de valeurs de référence pour les études épidémiologiques

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Abstract
The results of the steady state carbon monoxide test can be expressed quantitatively as the amount of CO absorbed by the lung per minute and per 1 mm Hg pressure difference (Tco; ml/min/mmHg) or as the ratios between partial pressures of CO (Fico, FECO, FACO), fractional uptake coefficient FUco = FICO – FECO/FICO; partial fractional uptake A, FUACO = F+CO-FECO/ FICO-FACO; and partial fractional uptake a, FUaCO = FICo - FACO/FICO From measurements taken in 141 non-smokers (mean age 47.43 ± 6.4 years), 60 ex smokers (mean age 45.73 ± 5.29 years) and 322 smokers (mean age 46.65 ± 5.5 years), TCO and fractional uptakes were calculated and discussed. Considering the fact hat mean TCO had a larger standard deviation than mean FUCO and that TCO had a non-Gaussian distribution, the authors chose to express the results of the test in fractional uptakes. Equations are proposed to calculate fractional uptakes.