Four benzodiazepine radioimmunoassays are described, the most sensitive of which can detect sub-therapeutic levels of bromazepam, chlordiazepoxide, clobazam, demoxepam, desalkylflurazepam, desmethyldiazepam, diazepam, flunitrazepam, lorazepam, medazepam, nitrazepam, oxazepam, prazepam, temazepam and triazolam. The standard curve for diazepam has a concentration range of 0–2·5 ng ml The assay is particularly applicable to blood samples of forensic interest that may be haemolysed or decomposing. A 75 μI sample is required. The antiserum and [3 H]flunitrazepam used are commercially available
- 1 September 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 32 (1) , 773-777
- https://doi.org/10.1111/j.2042-7158.1980.tb13064.x
Abstract
Four benzodiazepine radioimmunoassays are described, the most sensitive of which can detect sub-therapeutic levels of bromazepam, chlordiazepoxide, clobazam, demoxepam, desalkylflurazepam, desmethyldiazepam, diazepam, flunitrazepam, lorazepam, medazepam, nitrazepam, oxazepam, prazepam, temazepam and triazolam. The standard curve for diazepam has a concentration range of 0–2·5 ng ml The assay is particularly applicable to blood samples of forensic interest that may be haemolysed or decomposing. A 75 μI sample is required. The antiserum and [3 H]flunitrazepam used are commercially available.This publication has 22 references indexed in Scilit:
- Radioimmunoassay of diazepam in samples of forensic interestJournal of Pharmacy and Pharmacology, 1980
- A radioreceptor assay for benzodiazepinesJournal of Pharmacy and Pharmacology, 1979
- A radioreceptor assay for diazepam and its metabolites in serumClinica Chimica Acta; International Journal of Clinical Chemistry, 1979
- Pharmacokinetics of flunitrazepam following single- and multiple-dose oral administration to healthy human subjectsJournal of Pharmacokinetics and Biopharmaceutics, 1978
- Radioimmunoassay of the Anticonvulsant Agent ClonazepamJournal of Pharmaceutical Sciences, 1977
- Radioimmunoassay of Chlordiazepoxide in PlasmaJournal of Pharmaceutical Sciences, 1975
- Metabolic fates of flurazepam. I. Gas chromatographic determination of flurazepam and its metabolites in human urine and blood using electron capture detector.CHEMICAL & PHARMACEUTICAL BULLETIN, 1975
- Effects of Chronic Prazepam Administration on Drug Metabolism in Man and RatPharmacology, 1972
- Determination of 7-Bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one (Ro 5-3350) in Blood by Gas–Liquid ChromatographyJournal of Pharmaceutical Sciences, 1966
- Blood Level Distribution Patterns of Diazepam and its Major Metabolite in ManJournal of Pharmaceutical Sciences, 1966