Gas chromatography/mass spectrometry and gas chromatography/tandem mass spectrometry of methyl ester/methoxime/trimethylsilyl ether derivatives of prostaglandins

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Abstract
Electron impact mass spectra of methyl ester/trimethylsilyl ether derivatives of prostaglandin F2α and methyl ester/methoxime/trimethylsilyl ether derivatives of prostaglandin E2, prostaglandin D2, 6‐oxo‐prostaglandin F1α and 2,3‐dinor‐6‐oxo‐prostaglandin F1α are presented. Most of the prostaglandins studied have additionally been 2H‐labelled at different sites in order to assign the corresponding fragment ions. Collisionally activated decomposition mass spectra of the most intense parent ions in the high‐mass region were taken. High‐intensity, prostaglandin‐characteristic daughter fragments will allow a reliable quantification of prostaglandins in biological fluids and a reduction of sample clean‐up.