Effects of parathyroid hormone on urinary excretion of N-acetyl-β-D-glucosaminidase in idiopathic hypoparathyroidism and pseudohypoparathyroidism
- 31 October 1989
- journal article
- research article
- Published by Springer Nature in Calcified Tissue International
- Vol. 45 (6) , 375-377
- https://doi.org/10.1007/bf02556010
Abstract
N-acetyl-β-D-glucosaminidase(NAG) is a lysosomal enzyme predominantly located in renal proximal tubules. In idiopathic hypoparathyroidism(IHP), 100 Units of human PTH(1–34) increased urinary excretion of NAG from 0.029±0.027 to 0.173±0.035 U/1GF (p3 (1,25(OH)2D3 or 1αOHD3). In pseudohypoparathyroidism(PHP), PTH did not significantly increase the urinary excretion of NAG in one patient with before treatment (0.048 to 0.025 U/1GF) and four patients during treatment with active vitamin D3 (0.018±0.008 to 0.036±0.015 U/1GF). Increase in urinary excretion of NAG after injection of PTH may be a new indicator of renal effect of PTH.Keywords
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