Cloprostenol-induced luteolysis in the marmoset monkey (Callithrix jacchus)

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Abstract
A single i.m. injection of 0.5 .mu.g cloprostenol was not luteolytic on day 6 or 7 of the ovarian cycle (n = 3), but was luteolytic in some animals (3/5) on day 8 and 9 and luteolytic in all 23 animals treated between days 10 and 17 of the ovarian cycle and in 7 animals treated between days 19 and 43 of pregnancy. Luteal function was monitored by measurement of progesterone in peripheral blood using a simple and rapid non-extraction assay. There was a dramatic fall in peripheral blood progesterone to < 10 ng/ml within 24 h of cloprostenol injection; progesterone remained at this low level until the day after post-treatment ovulation. The interval from cloprostenol injection to ovulation in animals treated between days 8 and 17 was 10.7 .+-. 0.3 days. A similar interval was found in pregnant animals. Embryos recovered from the uterus after cloprostenol treatment were morphologically normal (23/24).