Effect of Adrenocorticotropin on Uptake of S35-Labelled Cysteine by Rat Adrenal Glands.

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Abstract
Values for total solid, protein, lipid and water-soluble content of the rat adrenal gland were determined. Total S content of the whole adrenal and the above fractions were measured. The whole adrenal S as determined (0.63%) was much lower than previously reported values. Adrenal glands were incubated for 20 minutes with radioactive L-cysteine and the tissue was then analyzed for total uptake of the isotope and its distribution within the fractions. The effect of added adrenocorticotropin upon this uptake and distribution was observed. The hormone preparation caused a 30% reduction in water-soluble radioactivity and a rise in the uptake by the lipid and protein fractions of 35% and 64% respectively.