A single chorionic gonadotropin assay for maternal serum screening for Down's syndrome
- 1 June 1990
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 10 (6) , 389-398
- https://doi.org/10.1002/pd.1970100606
Abstract
A simple enzyme immunoassay measuring human chorionic gonadotropin in undiluted maternal serum has been developed in order to be used as a prenatal screening test for Down' s syndrome. A retrospective study of maternal serum sampled during pregnancies associated with trisomy 21 shows that with a 5% amniocentesis rate determined on a single test, the detection rate of trisomy 21 would be around two‐thirds of the affected pregnancies. A prospective study of 9040 pregnant women under 38 years has confirmed the usefulness of the assay.Keywords
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