Testosterone Propionate Pellet Absorption in the Female

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Abstract
In a series of 63 [female][female] in whom 1 to 4 pellets of testosterone propionate were implanted subfascially for various gynecic disorders, it was noted that 28 suffered from nocturnal frequency. Although 19 of 28 [female][female] with this syndrome had fibromyomata uteri, the nocturia nevertheless was wholly or partially alleviated in all of them following the implantation. For this reason, the belief perpetuated in text books and teaching that nocturia associated with fibromyomata is due to pressure on the bladder may well be fallacious. Nocturia and diurnal distress for which no pathologic basis can be ascertained often prove refractive to the orthodox methods of treatment. Before contemplating surgery for the relief of this syndrome it is well to reconsider the role played by such factors as fibromyomata or a markedly anteflexed mobile uterus pressing unduly on the bladder or certain anatomic defects of the bladder such as mild cystocele or urethrocele. The frequency of bladder discomfort incident to these factors has been overstressed. The common tendency to operate upon such cases appears unwarranted before an ample course of estrogens or androgens has first been tried. Evidence has accumulated that the physiologic processes of the genito-urinary tract may be influenced by various hormones. Androgens are nephrotrophic. Testosterone exerts a specific action on kidney tissue. The reasons for the amelioration of certain disorders of micturition following steroid therapy may be a direct sequence to hormonal action either on kidney function, bladder tone, pituitary activity, water balance, electrolyte metabolism or some other mechanism at present not understood. Data indicate that sterile crystalline testosterone propionate pellets implanted subfascially will ameliorate the syndrome of nocturnal frequency herein described. From 25 to 400 mg. may well be used without fear of arrhenomimetic phenomena.

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