The Neuromuscular Blocking Action of Tetraethylammonium
- 1 September 1961
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 13 (1) , 752-758
- https://doi.org/10.1111/j.2042-7158.1961.tb11903.x
Abstract
The abnormally low activity of tetraethylammonium at the neuromuscular junction of the rat-diaphragm has been investigated. It seems possible to explain this lack of action in terms of the charge delocalisation and the stereochemistry of tetraethylammonium. The neuromuscular blocking activities of tetraethylammonium, isomers of it and related quaternary ammonium compounds have been determined and the structure activity relationships are discussedKeywords
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