Genetic Control of the Murine Cell‐Mediated Immune Response In Vivo

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Abstract
Various inbred and congenic strains of mice were immunized with the linear terpolymer L‐glutamic acid60‐L‐alanine30‐L‐tyrosine10 (GAT). Using a radioisotopic footpad assay to measure cell‐mediated immunity in vivo, mice with H‐2a, H‐2b, H‐2d, and H‐2k histocompatibility alleles showed a positive reaction, whereas mice with H‐2P and H‐2S alleles failed to respond. The ability of ‘responder’. lymphocytes to show an immune response resides in the thymus‐derived (T) lymphocyte population. Unfractionated spleen cells from H‐2q nonresponder mice, on transfer, showed no reactivity, whereas T‐cell‐enriched preparations were active.