Thorectandrols C, D, and E, New Sesterterpenes from the Marine Sponge Thorectandra sp.
- 12 March 2002
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 65 (4) , 492-495
- https://doi.org/10.1021/np010439k
Abstract
Extracts of the marine sponge Thorectandra sp. have been found to contain three new sesterterpenes, thorectandrols C (4), D (5), and E (6), together with the known compounds luffarin R (7), luffarin V (8), and palauolide (9). The structures were determined by extensive NMR spectral data analysis. Their relative stereochemistry was defined using NOE correlations and coupling constants, while CD data were used to suggest their absolute stereochemistry. Cytotoxicity data for compounds 4−9 as well as the previously reported compounds thorectandrols A and B and palauolol (1−3) against six or more human tumor cell lines are also reported.Keywords
This publication has 5 references indexed in Scilit:
- Thorectandrols A and B, New Cytotoxic Sesterterpenes from the Marine Sponge Thorectandra SpeciesJournal of Natural Products, 2001
- Siamenol, a New Carbazole Alkaloid from Murraya siamensisJournal of Natural Products, 2000
- Ultrahigh-Quality NOE SpectraJournal of the American Chemical Society, 1994
- High-field FT NMR application of Mosher's method. The absolute configurations of marine terpenoidsJournal of the American Chemical Society, 1991
- 13C chemical shifts of some model olefinsMagnetic Resonance in Chemistry, 1976