Soluble Polymeric Carriers for Drug Delivery: Part 5: Solution Properties and Biodistribution Behaviour of N-(2-Hydroxypropyl)Methacrylamide-co-N-(2-[4-Hydroxyphenyl]Ethyl) Acrylamide Copolymer Substituted with Cholesterol

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Abstract
A copolymer of N-(2-hydroxypropyl)methacrylamide (HPMA) and N-(2-[4-hydroxyphenyl]ethyl)acrylamide (HPEA) was derivatized with 2-4 mole% of N-(2-[(cholest-5-en-3-yl(3β)oxycarbonyl)oxypropyl]methacrylamide residues (cholesteryl residues). The effect of polymer modification on some of its solution properties, and on its behaviour in vivo in experimental animals, has been examined.

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