EPITHELIAL MUCOSUBSTANCES AND ARGYROPHIL CELLS IN BRENNER TUMOURS

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Abstract
Human Brenner tumors of various degree of malignancy were investigated by histochemical methods. Cells lining cystic cavities in the benign Brenner tumors contained various amounts of PAS[periodic acid-Schiff]-positive, diastase resistant secretory material mixed with small amounts of sulfo- and carboxymucin. Borderline and malignant tumors contained more acidic mucins than the benign tumors. All tumors contained glycogen. Argyrophil and argentaffin cells were detected in 12 of the 18 Brenner tumors. These cells were not proliferating, and therefore Brenner tumor should not be included in the group of APUDomas [amine precursor uptake and decarboxylation tumors].