Antibodies in Man Against Tahyna and Lumbo Viruses Determined by Hemagglutination-Inhibition and Tissue-Culture Neutralization Tests

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Abstract
Summary In comparative studies on human sera from Austria having hemagglutination-inhibiting (HI) antibodies to Tahyna virus, the quantitative correlation between HI and neutralization tests was exceedingly good. The neutralization test, however, proved slightly more sensitive. Neutralizing antibodies were assayed in HeLa cells by seeding cells and serum-virus mixtures simultaneously into culture tubes. In comparative studies done on sera from apparently healthy residents of West Africa that had been shown to react with Tahyna virus by HI test, the correlation between HI and neutralization tests was qualitatively similar to, but quantitatively different from, that obtained with the Austrian sera. It therefore seems reasonable to conclude that the HI antibodies in the West African sera are due to a California complex virus other than Tahyna. Some evidence is presented to suggest that this agent may be Lumbo virus.