FAILURE OF HAEMAGGLUTINATION AND IMMUNOFLUORESCENCE METHODS TO DETECT SERUM ORBITAL ANTIBODIES IN PATIENTS WITH GRAVES' OPHTHALMOPATHY

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Abstract
SUMMARY: Serum antibodies against human, bovine, and guinea‐pig, orbital antigens were tested for in patients with Graves' ophthalmopathy using haemagglutination and immunofluorescence techniques. Although low titres of antibodies were demonstrated in a small proportion of patients with Graves' ophthalmopathy, the prevalence was similar to that for normal subjects using both tests. The significance of these findings and the evidence for a role of autoantibodies in the pathogenesis of Graves' ophthalmopathy are discussed.