The Identification of Lymphocyte Clones, with Chromosome Structural Aberrations, in Irradiated Men and Women

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Abstract
A study has been made of the frequency with which two or more cells with an apparently identical stable chromosome aberration are found in preparations of blood cultures from heavily irradiated individuals. 133 patients have been examined following exposure to acute doses of x-rays or to chronic irradiation from retained thorium. The conditions are discussed in which such cells may be regarded as originating from a lymphocyte clone present in vivo, and four patients were found with unequivocal evidence of a clone. In undertaking comparative studies on irradiated subjects two important considerations appear to be the total number of cells scored with stable aberrations and the age of the subjects.