Three Different Acid Phosphatase Patterns in Leukaemic Lymphoid T-Cells

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Abstract
The acid phosphatase pattern was studied in leukemic cells from 8 patients with T[thymus-derived]-cell leukemia (5 ALL [acute lymphoblastic leukemia] and 3 CLL [chronic lymphiocytic leukemia]). In 2 cases enzyme activity was focal granular with paranuclear localization as earlier demonstrated by others while.sbd.in contrast to these findings.sbd.enzyme activity in 4 cases demonstrated universal granular distribution. Almost all the cells from each patient showed the same picture. In the last 2 cases a mixed focal and universal granular pattern was observed, where half the cells possessed the focal form and the other half the universal granular activity form. The 2 first-mentioned patterns were observed in cases of T-ALL and T-CLL, while the mixed pattern was seen only in T-ALL cases.