Mechanisms of Catalysis and Electron Transfer by Tryptophan Tryptophylquinone Enzymes
- 1 September 2002
- journal article
- research article
- Published by SAGE Publications in Progress in Reaction Kinetics and Mechanism
- Vol. 27 (3) , 209-241
- https://doi.org/10.3184/007967402103165397
Abstract
This review covers experimental works which have been carried out on the properties of the tryptophan tryptophylquinone (TTQ) cofactor and the TTQ-containing enzyme, methylamine dehydrogenase (MADH). The kinetic mechanism of MADH catalysed reactions, factors that determine the substrate specificity of MADH and the chemical reaction mechanism of MADH are discussed in detail. Electron transfer theory and kinetic models of interprotein electron transfer are discussed. Studies of electron transfer reactions in the MADH-amicyanin-cytochrome c551i protein complex are reviewed and discussed in terms of electron transfer theory.Keywords
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