The influence of naloxone infusion on the action of intrathecal diamorphine: low‐dose naloxone and neuroendocrine responses

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Abstract
The influence of an intravenous infusion of naloxone 1 μg kg‐1h‐1, in combination with intrathecal diamorphine, on analgesia and hormonal stress responses after laminectomy was assessed in a blinded, randomized, placebo‐controlled study. Twenty‐seven patients undergoing laminectomy with postoperative analgesia provided by intrathecal diamorphine were investigated. Analgesia was reduced by naloxone (PP<0.05). These results may indicate an excitatory role for the hypothalamic μ receptor in hypothalamo‐pituitary‐adrenocortical axis regulation.