Effect of Hg203-Labeled Mercaptomerin on Renal Sulfhydryl Concentration in Normal Rabbits.

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Abstract
Hg203-labeled mercaptomerin sodium, in a dosage of 14 to 30 mg of Hg/kg of body weight, was injected intravenously into normal rabbits immediately following a unilateral nephrecto-my, and the remaining kidney was removed 1 hour later. The mean cortical and medullary concentrations of Hg, were, respectively, 2.53 and 0.77 mg/g of dry weight of tissue. The mean sulfhydryl concentration in the control cortices was 10.08 mg/g of dry tissue, expressed as 1-cysteine; the mean value obtained 1 hour after administration of the tagged organic mercurial agent was 6.76 mg/g. The SH concentration of the cortex decreased in all 12 test animals following the injection of labeled mercaptomerin, and increased in the 2 uninjected control animals.

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