EXTRACTION AND RELEASE OF INDIVIDUAL FREE FATTY ACIDS BY THE HEART AND FAT DEPOTS*

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Abstract
The myocardial extraction of individual (FFA) and thier release by subcutaneous adipose tissue was investigated in man and dog. In the postabsorptive state, the human as well as the dog heart extracted a consistently higher percentage of free oleic acid than of any other FFA present in arterial blood. This acid was also released at a high rate by fat depots of the dog. These findings suggest a high turnover rate of free oleic acid. Several possibilities were examined to explain the high myocardial extraction of free oleic acid. It appears likely that an exchange between plasma triglycerides and free fatty acids in heart muscle resulting from lipo-protein lipase activity may be responsible.