Cyclic tetrapeptides with sequences related to HC toxin. Conformations and cation binding
- 1 December 1987
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 30 (6) , 801-807
- https://doi.org/10.1111/j.1399-3011.1987.tb03389.x
Abstract
Peptides with sequences related to HC toxin (cyclo(LAla-DAla-L-Aoe-DPro)) can adopt a conformation locked by three .gamma. turns. A "structure.sbd.spectroscopy characteristics" relationship is proposed. These peptides can complex Mg++ cations and the binding is accompanied by a transconformation of the peptide backbone. The relevancewith the biological activity of the toxin is discussed.Keywords
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